ENANTREX 300

Pharmacology

 Testosterone is responsible for the normal growth and development of the male sex organs and for the maintenance of the secondary sexual characteristics. The drug can affect the growth of the prostate, testis, seminal vesicles, penis and scrotum and also is important for body growth. Even though testosterone is an androgenic hormone, it does posses anabolic properties. Its use has been shown to promote protein synthesis and a positive nitrogen balance in the presence of a rich calorie diet.

Testosterone also has the ability to cause a mild increase in the production of red blood cells by stimulating the synthesis of EPO from the kidney. This results in an increase in the red blood cells and hence an increase in the oxygen carrying capacity.

When testosterone is taken for prolonged periods, it inhibits the release of Gonadotropins from the pituitary gland through a negative feedback mechanism. At large doses, it can even inhibit spermatogenesis.

Testosterone also has the ability to cause a mild increase in the production of red blood cells by stimulating the synthesis of EPO from the kidney. This results in an increase in the red blood cells and hence an increase in the oxygen carrying capacity.

When testosterone is taken for prolonged periods, it inhibits the release of Gonadotropins from the pituitary gland through a negative feedback mechanism. At large doses, it can even inhibit spermatogenesis.

Dose

Testosterone enanthate is only slowly released after an intramuscular injection and that is why it should not be taken more than 1-2 times a month. The formulation comes as an esterified preparation of testosterone which is only meant to be administered by an intramuscular injection. The esterification of the testosterone increases the duration of action of the testosterone. The preparation comes in a colorless to mild yellow suspension of sesame oil. For medical uses, a dose of 250-500mg is used once a month.

Indications

Delatestryl is indicated in the treatment of conditions where testosterone is either deficient or absent. These conditions include:

Primary hypogonadism- where the testes has been injured and fails to make the testosterone

Hypogonadism due to failure of the pituitary gland to release of Gonadotropins.

delayed puberty

In females with breast cancer, testosterone may help block the effects of estrogen and prevent further spread. It is an option instead of surgical removal of the ovaries.

In most cases of testosterone deficiency, therapy is required for a long time until the secondary sexual characteristic have been developed and the growth is adequate.

Duration

The treatment of all individuals with testosterone enanthate depends on age, sex, diagnosis and the response to treatment- and the onset of adverse effects. In general, the drug is well tolerated when prescribed as recommended. Delatestryl should always be injected in the buttock muscles and not simply underneath the skin. The injection site should be rotated to prevent abscess formation.  Another option is to inject the drug on the outside of the thigh. The drug should never be administered intravenously.

The dose of testosterone enanthate should not exceed more than 400 mg per month because the drug has prolonged activity. It is extremely rare to give this drug once every two weeks. The drug should always be inspected before injection. It is usually a colorless-yellow suspension which is clear. Any particulate matter or clumping indicates that the product is expired or inactive. The duration of treatment varies from 4-6 months.

The drug should be stored at room temperature.

Bodybuilders

A lot of bodybuilders use testosterone enanthate during the off season. The drug stays in the body for a long time and it is advisable not to use it during the active sports season. The drug definitely has anabolic and androgenic properties. However, the effects of the drug are not immediate and may take at least 3-4 weeks to become evident. Many bodybuilders also use other anabolic hormones like GH/thyroxin in combination.

Because testosterone is also converted to estrogen in the fatty tissues, many bodybuilders develop breast enlargement and retain water. The dose used to increase muscle mass and strength is about 250-1000 mg/week. However, at the higher doses the drug has potent side effects and it is highly recommended that all beginners start off with the low dose.

The increase in protein mass is gradual but does occur. Because the steroid also stimulates red blood cell production, many bodybuilders also notice that they have an increased capacity to perform under intense exercise conditions. Testosterone enanthate is preferred by most bodybuilders because it is readily available and has a number of benefits. It promotes good health, increase exercise performance and leads to a positive nitrogen balance. There are reports that it also selectively decreases fat and increases muscle mass. Recent studies from the World sports agencies indicate that this particular drug can boost performance, increase lean muscle mass and still not be detected in the urine within the first few weeks. Even when the anabolic effects are not obvious, most individuals do notice an increase in strength. Sometimes the water retention can be quite dramatic and some individuals do take a diuretic pill to remove it. To prevent the breast enlargement, testosterone enanthate is cycled with drugs like Arimidex or Tamoxifen. Most individuals take the testosterone for 4-6 weeks and then stop for a few weeks. During this wash out phase, one may use Arimidex.

Women

All testosterone analogues have the potential to cause virilizing effects when the duration of use is prolonged. In females, these virilizing signs may be deepening of voice, excessive hair growth, irregular menstrual cycles, mood alterations and clitoral enlargement. It is recommended that at the first sign of virilizing symptoms the drug should be stopped. The reason for this is that some of the virilizing signs may not be reversible even after discontinuation of the steroid.